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    <title>The Monitor on Psychology</title>
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    <copyright>Copyright 2020 American Psychological Association</copyright>
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        <guid isPermaLink="true">https://www.apa.org/monitor/2020/11/feature-2020-change</guid>
        <pubDate>Sun, 1 Nov 2020 23:26:19 +0000</pubDate>
        <link>https://www.apa.org/monitor/2020/11/feature-2020-change</link>
        <author>Trent Spiner</author>
        <title>How 2020 changed us</title>
        <description>Psychology leaders offer their take on how this has been a year of turmoil and transition</description>
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            <div class="wysiwyg lengthy" ><p>We can agree 2020 was an urgent call for all of us. Psychologists stood at the forefront of helping our country navigate a global pandemic, a national reawakening to systemic racism and epic natural disasters.</p>
<p>The science of psychology and the human brain have never been more critical. Your efforts helped parents and children adapt to homeschooling, employers and employees return to work safely, researchers find innovative ways to study, and health-care professionals and families cope with stress and loss.</p>
<p>To reflect on this tumultuous year, we asked 20 psychology leaders to answer the question, “How have the events of 2020 changed psychology, and what do they mean for the field’s future?” I hope their answers prompt you to reflect on the importance of the field and the challenges that lie ahead.</p>
<p><em>The Monitor on Psychology</em> also underwent change, as our previous editors, whose vision built this magazine into a wonderful resource, handed me the reins. I look forward to serving you as the new editor and documenting how your work, expertise and talents have an impact on making our world better for everyone.</p>
<p class="footnote"><strong>Trent Spiner</strong> is Editor in Chief of APA. Follow him on Twitter @TrentSpiner.</p> </div>

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<h2 >On racial inequality</h2>
            <div class="wysiwyg lengthy" ><img src="https://www.apa.org/images/2020-11-racial-inequality_tcm7-280545_w1024_n.jpg" alt="police in riot gear standing in front of a protester" data-aspect="0"  class="leftImg" style="width: 740px; height: 380px;"/>

<h3>Psychology must do more</h3>
<p>“The events of 2020 illuminate and challenge the core principles of the nation’s founding—liberty, justice, equality. We have never lived up to these ideals. Psychology needs to be a leader in understanding the nature of beliefs about justice, how people become fervently attached to their beliefs, how hard it is to change them and how variations in lived experience alter what justice means. Race is at the heart of this work, and psychology, which has done much over the years, needs to do more. We need to focus a laser light on systemic racism, exposing its damaging effects on all it touches. We need more voices, more guiding questions, more intention. The transactional relationships within and across racial boundaries must be better understood, and that understanding must lead to stronger bonds and mutuality. Developing approaches to building coalitions of the willing would be a major contribution to stanching the erosion of our democracy and building a better society.”</p>
<p><em>James M. Jones, PhD, is a professor emeritus of psychological and brain sciences and director of the Center for the Study of Diversity at the University of Delaware</em></p>
<h3>Equal access for all</h3>
<p>“These events have required psychology to respond to the oppressive systems plaguing our society and undergirding and perpetuating inequality for marginalized communities. Psychological science and understanding have been used to deepen conversations about health inequity, xenophobia, racism, bias, privilege, power, violence and more, on individual, organizational, community and societal levels. We have been called to use our skills to promote behavioral, affective and cognitive shifts that are long overdue and much needed. We have brought psychology to people in ways that have forever changed the scope of our reach. We are now well positioned to move toward a psychology of liberation that recognizes and supports the need for equal access to psychological services for everyone and leans into the best of our field to guide the world to a more ethical, just and free society.”</p>
<p><em>Shavonne J. Moore-Lobban, PhD, chairs APA’s Board for the Advancement of Psychology in the Public Interest and is the campus director of training at the Washington, D.C., campus of the Chicago School of Professional Psychology. </em></p>
<h3>Honor voices of color</h3>
<p>“COVID-19 has unveiled the stark inequities that communities of color experience in health, health care and recovery. But to address health and its psychological consequences, psychology must address the historical systems and structures that limit opportunities for health and the social discourse that dehumanizes the lived experience of communities of color. We must start by examining our bias and exclusion of communities of color. For far too long, we have studied these communities or treated their symptoms using our evidence and not theirs. Psychology can level the playing field by honoring the voices of communities of color and activating their expertise. By moving toward community partnerships and changing how research, practice and education are created and disseminated, we can position our field for sustained equity promotion and innovation.”</p>
<p><em>Carmen R. Valdez, PhD, is an associate professor at the Steve Hicks School of Social Work and chief of community engagement and health equity in the department of population health at Dell Medical School at the University of Texas at Austin.</em></p>
<h3>Diversify our scholarship</h3>
<p>“2020 has highlighted serious systemic inequities in many spheres of our lives, including law enforcement, health and health care. Unfortunately, inequities also underlie the work in my area, developmental psychology. Our research still focuses disproportionately on white participants. Our research agendas need to change to include more attention to the lives of Black and Brown children so that we better understand the manifestations of discrimination and oppression. More attention is needed to identify sources of resilience and their implications for later development, especially for children growing up in marginalized communities. This research can inform efforts to make schools and communities more supportive of the needs of Black and Brown children.”</p>
<p><em>Deborah L. Vandell, PhD, is president of Div. 7 (Developmental Psychology) and a professor of education at the University of California, Irvine.</em></p> </div>

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<h2 >On lives disrupted</h2>
            <div class="wysiwyg lengthy" ><img src="https://www.apa.org/images/2020-11-lives-disrupted_tcm7-280538_w1024_n.jpg" alt="woman with medical gloves holding a phone showing an older woman getting a hug" data-aspect="0"  class="leftImg" style="width: 740px; height: 380px;"/>

<h3>Pivoting to a new normal</h3>
<p>“Some of our colleagues became sick and recovered, some lives were lost to COVID and some colleagues lost jobs or their finances were hit hard. Practice transitioned rapidly to telephone and telehealth platforms and included service provision to first responders, nurses and physicians. Education, training and clinical science research changed to maintain safety. Flexibility and perseverance were vital, and we are continuing to educate ourselves, encourage institutional anti-racism policies, support practice and engage in advocacy.”</p>
<p><em>Monica Kurylo, PhD, ABPP, is president of Div. 31 (State, Provincial and Territorial Psychological Association Affairs) and professor and director of neurorehabilitation psychology at the University of Kansas Medical Center &amp; KU Health System.</em></p>
<h3>New challenges</h3>
<p>“COVID-19 had a major acute effect on psychological research by dramatically disrupting in-person data collection. This will have long-term impacts, including greater use of online behavioral assays and redesign of procedures for in-person behavioral testing. The pandemic also has dramatically disrupted undergraduate and graduate research, and adapting lab classes for online learning is a particularly great challenge. George Floyd’s murder has catalyzed a movement for racial justice in the United States and beyond, including intense attention on equity, diversity and inclusion in psychology. One important domain is how psychologists—especially BIPOC psychologists—are recruited, trained and supported in careers. Another is recognizing the limitations of relying on convenience samples such as college students who may not be diverse in race, ethnicity or class.”</p>
<p><em>Jeffrey Zacks, PhD, is the chair of APA’s Board of Scientific Affairs and a professor in the department of psychological and brain sciences at Washington University in St. Louis.</em></p>
<h3>Global behavior change</h3>
<p>“The biggest lockdown in our lifetime called for a sea change in our everyday behaviors: wearing masks, physically distancing and switching to the use of technology for teaching and learning, providing services and conducting business. Ignoring behavioral changes has cost us surges in disease incidence and death rates in some places. Compounding the COVID crisis were the police killings of George Floyd and Rayshard Brooks, causing protests worldwide calling to eradicate racism. Psychologists globally should have a clear mission to help us move to more peaceful, civilized and healthy societies by aggressively promoting research on bringing about behavioral changes at the societal level for better physical and mental health; eradicating racism, poverty and societal violence; and how best to use media and technology to disseminate authentic information globally to achieve these goals.”</p>
<p><em>V. Krishna Kumar, PhD, is president of Div. 46 (Society for Media Psychology &amp; Technology) and a psychology professor at West Chester University. </em></p>
<h3>Shared vulnerability</h3>
<p>“Therapists have come to know a different level of mutual experience with patients. We no longer have the privilege of offices with our familiar protocols of engagement. We have all had to recognize our vulnerability and the anxiety of a public health crisis that touches every one of us. In spite of the trauma that we inhabit, we will continue to create ways of engaging one another that privilege relationships and the recognition of our radical humanity.”</p>
<p><em>Joseph Schaller, PsyD, is president-elect of Div. 39 (Society for Psychoanalysis and Psychoanalytic Psychology) and a clinical psychologist in Philadelphia. </em></p> </div>

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<h2 >On trauma & uncertainty</h2>
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<h3>A time of unparalleled stress</h3>
<p>“Increases in mental health concerns are occurring, including increased stress, anxiety, depression, domestic violence and the consequences of unemployment. Although economic downturns typically predict increased stigma against devalued groups, it is possible that many elements of society will come to realize how precious life and mental health are—with consequent increases in empathy and compassion, and with increased access to evidence-based services via telehealth here to stay. Such would be truly silver-lined outcomes; major resources must be committed to ensure equitable access. And in terms of the huge rise in racism-linked consciousness, the ultimate goal—transcending expectable and justified outrage expressed throughout our nation—is for sustainable actions. We need to open all aspects of society, and our profession, to diverse individuals and to realize that we must all become aware of the institutionalized pervasiveness of racism.”    </p>
<p><em>Stephen P. Hinshaw, PhD, is president of Div. 53 (Society of Clinical Child and Adolescent Psychology) and a professor of psychology at the University of California, Berkeley.</em></p>
<h3>An evolving landscape</h3>
<p>“The social strife and physical distancing of 2020 have been humbling and reminded us that we are emotional beings. While technology offers new virtual solutions in psychology, our fundamental roots for connectedness, community and public service run deep. We must be careful to not let the rapidly changing world disrupt our important ancient psychological and societal foundations. The challenge for psychologists moving forward is to foster and maintain these foundations in our evolving landscape of telehealth and virtual communication, job automation, social media and disparate access to digital information.”</p>
<p><em>Jack Tsai, PhD, is president of Div. 18 (Psychologists in Public Service) and campus dean for the University of Texas School of Public Health. </em></p>
<h3>Broadening the lens</h3>
<p>“The pandemic has seen many people without traditional diagnoses struggling with emotional and psychological concerns. This means that psychology must take seriously the use of population-level models so that our discipline can better serve communities in culturally appropriate ways, with maximum impact. Widespread attention to systemic racism underscores the need for our field to continue broadening its lens to become more centrally integrated and multicultural. This approach is needed to address other global issues, including COVID-19, violence and climate change. And as technology continues to play a huge role in communication and health care, psychology has a key role to play in developing effective and ethical human-technology interfaces and innovations.”</p>
<p><em>Sandra L. Shullman, PhD, is APA’s president and a partner in the Executive Development Group consulting firm in Greensboro, North Carolina.</em></p>
<h3>A time for reason</h3>
<p>“2020 revealed that people struggle with decisions that require assessing and balancing risks to self and to others, economic outcomes, personal freedoms and civil interaction. The science of decision-making should be taking center stage, but too often citizens and policymakers are retreating to emotion and intuition rather than reason. Once we are no longer in the middle of these crises, I hope a retrospective examination of the events of 2020 will provide an opportunity for psychology to advocate for more effective risk communication and the systematic evaluation of trade-offs.”</p>
<p><em>Michael Young, PhD, is chair of the Council of Graduate Departments of Psychology and the psychological sciences department head at Kansas State University. </em></p> </div>

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<h2 >On psychology's potential</h2>
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<h3>Our science is critical</h3>
<p>“The plagues of 2020 forever politicized scientific storytelling. The year began with Australia on fire, transitioned to a global pandemic and reignited flames of protest against racist state violence. The thread that unites these tragedies is that science can help avert them. Additionally, each scientific literature—from climate change to viral contagion to racial bias—is deeply politically contested. That means reporting our science clearly for a general audience is vital. It also means that, for much of our science, it is not possible to report our findings responsibly outside of the political context. Anthropologists will say that it never was. But 2020 makes that fact undeniable. My hope is that, as we move toward 2021, we embrace the necessarily political nature of studying the human mind. Politics is about power, and no scientist should pretend our field exists outside of that.”</p>
<p><em>Phillip Atiba Goff, PhD, is the co-founder and CEO of the Center for Policing Equity and a professor of African American studies and psychology at Yale University.</em></p>
<h3>Never more important</h3>
<p>“If one considers the breadth of individual and societal responses to the pandemic, from fear about infection and coping with bereavement to the disruption of children’s lives due to school closures to the impact of loneliness and economic disruption on well-being, I cannot think of any single discipline whose relevance is more urgent and pervasive than psychology. The diverse contributions of psychological science, in particular our understanding of how environments and personal skills can be modified to address the consequences of the unprecedented stressors affecting all of us, need to be acknowledged and scaled up to mitigate the adverse impacts that are already becoming visible and will only worsen in the coming months. Never has psychology been as important as now.”</p>
<p><em>Vikram Patel, PhD, is the Pershing Square Professor of Global Health in the department of global health and social medicine at Harvard Medical School.</em></p>
<h3>A place at the table</h3>
<p>“The crises of 2020 have inspired many psychologists to conduct timely research and engage in outreach. The public has realized that behavioral science is necessary to understand many of the most important issues of the day. From understanding racism to addressing political polarization to promoting effective responses to the pandemic, psychologists should be part of the discussion. For most of my life, fields like economics have driven most of the conversation. But I hope that psychology research and practice will have a seat at the table to help people separate science from science fiction. Our work is relevant to many of the most important issues facing society and should receive more robust funding.”</p>
<p><em>Jay Van Bavel, PhD, is an associate professor of psychology and neural science at New York University.</em></p>
<h3>A global awakening</h3>
<p>“The traumatic events of 2020 put psychology front and center, as the world became aware of what psychology has to offer, from the use of psychological science to understand systemic racism and people’s behavior during this most challenging time to changing behaviors and making psychological services available to others during a time of physical distancing and extreme distress. The way we practice psychology changed as we were forced to do things differently to continue to reach vulnerable populations. It was a learning experience, and the practice of psychology will be forever changed.”</p>
<p><em>Jennifer F. Kelly, PhD, ABPP, is APA’s president-elect and director of the Atlanta Center for Behavioral Medicine. </em></p> </div>

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<h2 >On moving forward </h2>
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<h3>A Time to speak up</h3>
<p>“The COVID-19 pandemic has forced psychologists to recognize that the world is faced with catastrophic conditions, such as pandemics, climate change and loss of biodiversity. It has also shown that in a world full of inequalities, solidarity plays an essential role. The pandemic has also confirmed long-standing arguments that nuclear weapons, massive armies and border walls do not make humans more secure. The killing of George Floyd has forced psychologists to reckon with racism, discrimination and police violence. Psychologists can only go forward by grasping causal links between economic development, disappearing biodiversity, climate change and pandemics. Psychologists must prioritize public health over private interests and stop the forces that cripple health services. Psychologists must choose peace over militarism: Militarism wastes funds that should go to public health and puts the world in danger. Psychologists must prioritize addressing racism and discrimination across the world and in their own work settings, organizations and structures.”</p>
<p><em>Serdar M. Değirmencioğlu, PhD, is the past president of Div. 48 (Society for the Study of Peace, Conflict, and Violence) and a professor at the University of Hagen in Germany.</em></p>
<h3>Confront assumptions</h3>
<p>“The events of 2020 have unmasked the depth of psychological dysfunction in society. Artificially constructed social hierarchies perpetuate major psychological challenges such as racism; intergenerational poverty; inequities in education, health and wealth; and global climate change. Going forward, psychologists will need to make it a priority to challenge and retire existing hierarchical assumptions that perpetuate these psychological stressors and work toward interventions to transform hierarchical social systems and behavior that interfere with psychological wellness.”</p>
<p><em>Art Blume, PhD, is president of Div. 45 (Society for the Psychological Study of Culture, Ethnicity and Race) and a professor of psychology at Washington State University in Vancouver. </em></p>
<h3>Be nimble</h3>
<p>“2020 has changed how we deliver and apply our science to address human suffering, whether that’s through telehealth for individual patients, applications of what we know about health behavior to large public health issues or advocacy for social justice. Going forward, we need to remain nimble to meet the needs of those we serve.”</p>
<p><em>Zeeshan Butt, PhD, is the past president of Div. 38 (Society for Health Psychology) and an associate professor at the Northwestern University Feinberg School of Medicine. </em></p>
<h3>Improve lives everywhere</h3>
<p>“One encouraging experience to come out of this tough time has been the bond people have for valuing human life and how psychologists have been able to help increase awareness of social justice issues, and the ability of our clinical acumen, research and innovation to be impactful during such crises. This shift speaks to the strength of psychology to be a voice and a mechanism to navigate societal issues and crises; never is this more evident than now. This is a time to speak up, advocate and share all the knowledge we have so that we help advance our human race.”</p>
<p><em>Erika Carr, PhD, is an associate professor and the director of the inpatient psychology service at Yale University School of Medicine and the chair of APA’s Committee on Early Career Psychologists.</em></p> </div>

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        <pubDate>Tue, 3 Nov 2020 23:26:19 +0000</pubDate>
        <link>https://www.apa.org/monitor/2020/11/news-music-power</link>
        <author>Trent Spiner</author>
        <title>Music’s power over our brains</title>
        <description>Armed with more interest and funding, researchers are investigating how music may enhance brain development and academic performance and even help people recover from COVID-19</description>
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            <div class="wysiwyg lengthy" ><p>One of the most poignant early images of the coronavirus pandemic was of Italians playing music and singing from their balconies even as the virus ravaged their cities. Others soon followed suit, including pop stars streaming live performances from their homes and choirs sharing concerts via Zoom—all trying to provide connection during a frightening and uncertain time.</p>
<p>Of course, music has been bringing people together for millennia, and not just during crises. And in the last few decades, investigators have been training their attention on the so-called universal language of music—how it affects our brains and how it might be used to facilitate health and healing. That interest is now being fueled by new research attention and funding: In June, the Global Council on Brain Health, an independent science and policy collaborative devoted to understanding brain health, released a <a href="https://www.aarp.org/content/dam/aarp/health/brain_health/2020/06/gcbh-music-report-english.doi.10.26419-2Fpia.00103.001.pdf" target="_blank">report</a> concluding that music has “significant potential to enhance brain health and well-being for individuals of different ages and different levels of health” and making recommendations for future study. And last year, <a href="https://www.nih.gov/research-training/medical-research-initiatives/sound-health" target="_blank">Sound Health</a>, a program launched by the National Institutes of Health (NIH) and the Kennedy Center, in association with the National Endowment for the Arts (NEA), awarded $20 million over five years to support its first 15 research projects on the topic, including several headed by psychologists.</p>
<p>“Why is music so captivating for us?” asks Thomas Cheever, PhD, staff assistant to NIH Director Francis Collins, MD, PhD, for Sound Health and a program director at the National Institute of Neurological Disorders and Stroke. “The more we understand about that, the more fascinating it’s going to be, and the more we are going to learn about how the brain works in general.” Psychologists and neuroscientists are particularly interested to find out which neural pathways are affected by music, how music influences children’s development, and how music interventions may help people with a range of physical and mental health conditions, including Alzheimer’s disease, schizophrenia, delirium and Parkinson’s disease.</p>
<p>And they are adding COVID-19 to the conditions they are trying to ease. Babar A. Khan, MD, assistant professor of medicine at the Indiana University School of Medicine in Indianapolis, for example, is using a Sound Health grant to test a music intervention with patients who have delirium, including those with COVID-19. Delirium—an acute, short-term condition marked by confusion and emotional disruption—afflicts as many as 80% of patients who are in the intensive care unit for respiratory failure, including those with COVID.</p>
<p>If the intervention proves helpful, says Khan, “it will be used immediately during the course of the current pandemic.”</p>
<h2>Enhancing child development</h2>
<p>One ongoing research interest is how music may affect youth in terms of language development, attention, perception, executive function, cognition and social-emotional development. Psychologist Assal Habibi, PhD, an assistant research professor at the University of Southern California Dornsife’s Brain and Creativity Institute, has been investigating these topics for the past seven years in collaboration with the Los Angeles Philharmonic Youth Orchestra, known as YOLA, an after-school program that brings low-income youngsters together to learn, play and perform music. Now in its final year, the study has been tracking brain and learning outcomes of 75 children who are either participating in YOLA, a community sports program or no after-school program.</p>
<p>Data published from the first few years of the intervention show that YOLA participants gradually develop auditory and cognitive advantages over youth who aren’t involved in music. After the second year of the study, the YOLA participants showed greater ability to perceive pitch, rhythm and frequency of sounds, as well as enhanced development in the auditory pathway, the neurological route that connects the inner ear to auditory association areas in the brain (<a href="https://doi.org/10.1016/j.dcn.2016.04.003" target="_blank"><em>Developmental Cognitive Neuroscience</em></a>, Vol. 21, 2016). After the third and fourth years in the program, they also began to perform better on tasks unrelated to music, including on executive function tasks involving working memory and delayed gratification—likely because of the discipline required to patiently learn pieces of music, Habibi says. In addition, youth involved in YOLA showed greater development in brain areas related to language and auditory processing, and greater neuronal connectivity in the corpus callosum, the nerve bundle that connects the brain’s right and left hemispheres (<a href="https://doi.org/10.1093/cercor/bhx286" target="_blank"><em>Cerebral Cortex</em></a>, Vol. 28, No. 12, 2018).</p>
<p>“We obviously expected their musical skills to get better,” she says, “but it seems a broad range of other skills are also impacted by music.”</p>
<p>Habibi now has a grant from the NEA to follow these same children into adolescence to see whether the brain benefits they derived early on translate into real-life behaviors and decisions as teens—choice of peers, for example, or whether they show up to class. She also has an NIH Sound Health grant to compare differences in executive functioning among bilingual youth who are learning music and those who are learning music but only speak one language.</p>
<p>“As a developmental psychologist, I don’t think there’s just one pathway to better executive function in children,” she explains. “So, it will be interesting for us to identify different mechanisms and understand how each one works.”</p>
<h2>Music and mental illness</h2>
<p>Researchers are also exploring whether music may prove to be a helpful therapy for people experiencing depression, anxiety and more serious mental health conditions. A study of 99 Chinese heart bypass surgery patients, for example, found that those who received half an hour of music therapy after the operation—generally light, relaxing music of their own choice—had significantly lower self-reports of depression and anxiety than those who rested or received conventional medical check-ins in the same time frame (<a href="https://link.springer.com/article/10.1186/s13019-020-01141-y" target="_blank"><em>Journal of Cardiothoracic Surgery</em></a>, Vol. 15, No. 1, 2020). Meanwhile, in conjunction with the Global Council on Brain Health’s strong endorsement of more research on music and brain health, an AARP survey of 3,185 adults found that music has a small but statistically significant impact on people’s self-reported mental well-being, depression and anxiety.</p>
<p>Others are examining whether music interventions could benefit those with serious mental illness. Yale experimental psychologist and cognitive neuroscientist Philip Corlett, PhD, for example, will use a Sound Health grant to test an intervention in which people with schizophrenia come together to write and perform music for one another. The work builds on Corlett’s developing model of schizophrenia, which maintains that people with the disorder have difficulty revising and updating their views of self and reality based on newly emerging events, considered a central feature of the healthy human brain. Making music with others—which involves both positive social interactions and a type of expression with predictable outcomes—could allow participants to experience more realistic predictions and hence foster their sense of predictability and security, he hypothesizes.</p>
<p>“If we can show that music-making changes the mechanisms that we think underwrite these symptoms [of schizophrenia],” Corlett says, “then we can figure out its active ingredients and ultimately come up with ways to deliver this to people who need it.”</p>
<h2>Therapy for older adults</h2>
<p>The impact of music on older adults’ well-being is likewise of keen interest to researchers, who are looking at how music therapy may help verbal fluency and memory in people with Alzheimer’s disease (<em>Journal of Alzheimer’s Disease</em>, Vol. 64, No. 4, 2018) and how singing in a choir may reduce loneliness and increase interest in life among diverse older adults (<a href="https://doi.org/10.1093/geronb/gby132" target="_blank"><em>The Journals of Gerontology: Series B</em></a>, Vol. 75, No. 3, 2020). Music even shows promise in preventing injury: A study by Annapolis, Maryland–based neurologic music therapist Kerry Devlin and colleagues showed that music therapy can help older adults with Parkinson’s disease and other movement disorders improve their gait and reduce falls (<a href="https://doi.org/10.1007/s11910-019-1005-0" target="_blank"><em>Current Neurology and Neuroscience Reports</em></a>, Vol. 19, No. 11, 2019).</p>
<p>Still others are investigating how music can help people recover from serious illnesses and conditions, including, now, COVID-19. In a pilot study, Khan of Indiana University showed that patients with delirium on mechanical ventilators who listened to slow-tempo music for seven days spent one less day in delirium and a medically induced coma than those listening to their favorite music or to an audio book (<a href="https://doi.org/10.4037/ajcc2020175" target="_blank"><em>American Journal of Critical Care</em></a>, Vol. 29, No. 2, 2020). Now, with his Sound Health grant, he is comparing the effects of slow-tempo music or silence on 160 participants with delirium, including COVID-19 patients on ventilators in hospitals in Indianapolis.</p>
<p>Studies like these underscore music’s potential as a safe and effective medical intervention, as well as the importance of conducting more research on which kinds of music interventions work for whom, when and how, including during this difficult time, adds Cheever.</p>
<p>“How do we get [music therapy] into the same realm as other interventions that are the standard of care for any given indication?” he says. “The answer to that, I think, is a solid evidence base.”</p> </div>

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<h2 >Further reading</h2>
            <div class="wysiwyg lengthy" ><p>NIH/Kennedy Center Workshop on Music and the Brain: Finding Harmony
<br />
Cheever, T., et al., <em>Neuron</em>, 2018</p>
<p><a href="https://www.frontiersin.org/articles/10.3389/fnins.2019.01080/full" target="_blank">Effects of Music Training on Inhibitory Control and Associated Neural Networks in School-Aged Children: A Longitudinal Study</a>
<br />
Hennessy, S.L., et al., <em>Frontiers in Neuroscience</em>, 2019</p>
<p><a href="https://aacnjournals.org/ajcconline/article/29/2/e31/30855/Decreasing-Delirium-Through-Music-A-Randomized" target="_blank">Decreasing Delirium Through Music: A Randomized Pilot Trial</a>
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Khan, S.H., et al., <em>American Journal of Critical Care</em>, 2020</p> </div>

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        <guid isPermaLink="true">https://www.apa.org/monitor/2020/11/attacks-brain</guid>
        <pubDate>Sun, 1 Nov 2020 23:26:19 +0000</pubDate>
        <link>https://www.apa.org/monitor/2020/11/attacks-brain</link>
        <author>editorial@apa.org (Kirsten Weir)</author>
        <title>How COVID-19 attacks the brain</title>
        <description>Researchers are scrambling to understand just how COVID-19 impacts the brain and what scientists can do to prevent long-term damage</description>
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            <div class="wysiwyg lengthy" ><p>As the COVID-19 pandemic rocketed around the globe, it quickly became clear that this was not your average respiratory illness. The disease appears to affect a number of body systems, including the heart and the brain. Early on in the pandemic, there came reports that many people with the disease had lost their sense of smell, a curious symptom suggesting the virus may affect the nervous system. As more people became infected, accounts of strokes and other neurological complications started coming in. (For more on the possible disease processes involved in these neurological complications, see <em>Multiple disease processes</em> below.)</p>
<p>“There’s documented evidence that patients who are hospitalized with moderate and severe COVID-19 experience a range of neurological, cognitive, psychological and psychiatric symptoms—and I’ve seen them myself,” says Robert Stevens, MD, FCCM, a physician in the intensive care unit (ICU) at Johns Hopkins Medicine who treats patients with critical neurological illnesses. “Virtually all the COVID-19 patients I’ve treated in the ICU have delirium.”</p>
<p>It’s not yet clear how common neurological side effects are in hospitalized patients, let alone in people with less severe respiratory symptoms who don’t spend time in hospitals. “The picture is still evolving,” Stevens says.</p>
<p>In a review of case reports from 901 COVID-19 patients, Mark Ellul, at the University of Liverpool, and colleagues reported a range of neurological manifestations, including loss of smell and taste, confusion, encephalitis (inflammation in the brain), and Guillain-Barré syndrome (a disorder in which the immune system attacks the body’s nerves) (<a href="https://doi.org/10.1016/S1474-4422(20)30221-0" target="_blank"><em>The Lancet Neurology</em></a>, published online, 2020). A case report of 58 patients from France described neurological findings in 67% of patients (Helms, J., et al., <a href="https://www.nejm.org/doi/full/10.1056/NEJMc2008597" target="_blank"><em>The New England Journal of Medicine</em></a>, Vol. 382, No. 23, 2020).</p>
<p>The prevalence of neurological problems remains an open question, but it’s safe to conclude that “neurological problems are not rare for COVID-19 patients,” says Majid Fotuhi, MD, PhD, medical director of NeuroGrow Brain Fitness Center and lead author of a comprehensive review of COVID-19’s effects on the nervous system (<em><a href="https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200581" target="_blank">Journal of Alzheimer’s Disease</a></em>, Vol. 76, No. 1, 2020). “Our best estimate so far is that 30% to 50% of hospitalized patients have neurological issues,” he says.</p>
<p>In their review, Fotuhi and his colleagues describe the variety of neurological complications in patients with COVID-19. “There’s a wide range of symptoms, including headaches, dizziness, weakness, confusion, eye movement problems, seizures and paralysis,” he says. “The two most common neurological problems seem to be stroke and delirium.”</p>
<p>In general, people who experience more serious symptoms of COVID-19 tend to have more brain-related complications, Fotuhi says. “Broadly speaking, the sicker they are, the more neurological issues they have.” But there are exceptions to that rule. A study by scientists in England of 43 patients with severe neurological complications from COVID-19 found that some patients had relatively mild respiratory symptoms (Paterson, R.W., et al., <a href="https://doi.org/10.1093/brain/awaa240" target="_blank"><em>Brain</em></a>, published online, 2020).</p>
<h2>Pandemic neurology: Past, present &amp; future</h2>
<p>As researchers continue to gather evidence about COVID-19 and the brain, they’re turning to past epidemics for clues. “The 1918 influenza pandemic was associated with a surge in neurological problems, many of which became apparent months or years later,” Stevens says. The SARS outbreak in 2003 and MERS outbreak in 2012—both caused by coronaviruses similar to the one that causes COVID-19—were also associated with neurological illnesses, including inflammation in the brain. And following each of those outbreaks, Stevens says, “there were reports of people suffering long-lasting neurological injuries.”</p>
<p>Neurology experts are concerned that COVID-19 could leave a similar legacy. But many questions remain, Fotuhi says. “The first step is to document what neurological symptoms occur, at what frequency, and what treatments have or have not affected the neuropsychological symptoms.”</p>
<p>So far, studies of patients with the disease haven’t really drilled down into neuropsychological outcomes, Stevens says. “Trials of antivirals and other therapies being tested to treat COVID-19 are looking at some very coarse outcome measures, like survival or duration of hospitalization. The scientific community needs to include neurological, psychological and psychiatric outcomes as well,” he says.</p>
<p>Experts around the world are working to make that happen. Researchers from 70 sites and 15 countries have registered with the Global Consortium to Study Neurological Dysfunction in COVID-19. The collaborative effort, endorsed by the Neurocritical Care Society, is collecting data and evaluating functional and cognitive outcomes to inform treatment strategies (Frontera, J., et al., <a href="https://link.springer.com/article/10.1007/s12028-020-00995-3" target="_blank"><em>Neurocritical Care</em></a>, Vol. 33, No. 1, 2020). But physicians shouldn’t wait until all the data are in to start intervening, Stevens suggests. Existing therapies are available to treat autoimmune encephalitis, for example. “But these haven’t yet been studied specifically in COVID-19 patients,” he says.</p>
<p>The faster such treatments are tested, the better, Stevens adds, since some of the brain damage from COVID-19 may be irreversible. But Fotuhi is hopeful that for some people, interventions may restore brain function. “Targeted brain training may be able to address specific cognitive symptoms, such as difficulty with executive function or memory,” he says. “I think there will be a great need for psychologists to get involved, to help patients recognize their symptoms and seek treatment for them.”</p> </div>

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<h2 >Multiple disease processes</h2>
            <div class="wysiwyg lengthy" ><p><strong>Researchers are working around the clock to understand how COVID-19 is affecting the brain. It’s likely that there are several different disease processes at work.</strong></p>
<h2>Complications from intensive care</h2>
<p>People who have been hospitalized in the ICU, for any reason, are more likely to experience long-term problems with cognition and have an increased risk of anxiety and depression. One (pre-COVID-19) study found 20%–40% of ICU patients experienced delirium, with rates climbing to 60%–80% for patients on ventilators (Pandharipande, P.P., et al., <a href="https://link.springer.com/content/pdf/10.1007/s00134-017-4860-7.pdf" target="_blank"><em>Intensive Care Medicine</em></a>, Vol. 43, No. 9, 2017). Such complications are thought to be related both to severe illness and to intensive care treatment. Some portion of people seriously ill with COVID-19 will likely experience <a href="https://www.apa.org/monitor/2020/09/aftermath-covid-19">delirium and other neurological side effects</a> simply as a result of being in the ICU, says Robert Stevens, MD, FCCM, of Johns Hopkins Medicine.</p>
<h2>Inflammatory or immune response</h2>
<p>In some patients, COVID-19 seems to trigger a runaway immune response that can cause problems throughout the body. In their Brain study of patients with neurological complications, Ross W. Paterson, PhD, of University College London, and colleagues described several types of encephalitis, as well as acute disseminated encephalomyelitis, or ADEM (an autoimmune disorder in which the immune system attacks the brain). Patients with encephalitis may experience mild flu-like symptoms, such as headaches, fevers and fatigue, or may experience more severe symptoms including confusion, seizures, paralysis, problems with speech or hearing, and more.</p>
<h2>Stroke</h2>
<p>COVID-19 has been found to cause blood clots, both large and small, that can travel to the brain and cause a stroke. Strokes have occurred in COVID-19 patients of all ages—and in fact, physicians have reported that some adults under 50 have presented to the hospital with a stroke as their first complication from COVID-19, while their respiratory symptoms were mild (Oxley, T.J., et al., <a href="https://www.nejm.org/doi/full/10.1056/NEJMc2009787?query=featured_home" target="_blank"><em>The New England Journal of Medicine</em></a>, Vol. 382, No. e60, 2020).</p>
<h2>Viral infection of the brain</h2>
<p>There have been a handful of accounts of the virus turning up in cerebrospinal fluid, raising the possibility that SARS-CoV-2, the virus that causes COVID-19, may be able to directly infect brain cells. But the evidence that the virus can make its way into brain cells is still uncertain, both Majid Fotuhi, MD, PhD, of NeuroGrow Brain Fitness Center, and Stevens agree. “Based on the literature and what we’ve seen so far, if viral infection of the brain occurs, it’s probably pretty rare,” Stevens says. “We think that immune-mediated encephalitis is probably much more common.”</p>
<h2>A neurological framework</h2>
<p>To integrate these concepts and form a preliminary framework for studying COVID-19 in the brain, Fotuhi and colleagues have proposed a three-stage system to classify neurological complications from the disease:</p>
<ul>
<li><strong>Stage 1:</strong> Damage to the nervous system is limited to the epithelial cells in the nose and mouth. The main neurological symptoms include loss of smell and taste. These side effects seem to be quite common. One study found smell reduction in 41.7% of people with COVID-19, while 55.4% experienced taste reduction (Mercante, G., et al., <a href="https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2767510" target="_blank"><em>JAMA Otolaryngology—Head &amp; Neck Surgery</em></a>, published online, 2020).</li>
<li><strong>Stage 2:</strong> The virus triggers an inflammatory response that leads to the formation of blood clots, which can cause strokes.</li>
<li><strong>Stage 3:</strong> A explosive inflammatory response called a cytokine storm damages the blood-brain barrier. This may allow inflammatory cells and molecules—and possibly viral particles—to enter the brain. Patients may develop seizures, confusion, coma or encephalopathy (a brain abnormality that leads to altered mental states or behaviors).</li>
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